Mezo has introduced Mezo Prime, a new offering aimed at institutions and corporate treasuries holding Bitcoin, addressing a long-standing gap between passive custody and active capital deployment.
The product is designed for firms that have historically kept BTC idle due to limitations around control, reporting, and risk management in existing yield solutions.
At the core of Mezo Prime is a segregated custody model built around “Enclaves,” dedicated Bitcoin vaults that isolate assets per depositor. Custody is provided by Anchorage Digital Bank, ensuring that assets are not commingled and are held within a regulated framework.
Yield generation without rehypothecation
Bitcoin deposited into an Enclave can be deployed in two primary ways: locked as veBTC to earn protocol-generated fees or used as collateral to borrow MUSD, Mezo’s Bitcoin-backed stablecoin.
The structure is designed to provide yield while maintaining institutional safeguards, including no rehypothecation and full asset segregation. This approach targets CFOs and treasury teams seeking to activate Bitcoin holdings without compromising security or compliance.
The product is available directly through Anchorage Digital’s platform, giving existing institutional clients access without requiring new custody arrangements.
“Over a million Bitcoin sits on corporate balance sheets today, and almost none of it is working,” said Matt Luongo, co-founder of Mezo and CEO of Thesis. “Mezo Prime changes that. Segregated custody through Anchorage Digital Bank, no rehypothecation, real yield from protocol activity. We built this for the CFOs and treasury teams who already own the asset and are ready to put it to work how they choose.”
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Bullish, a publicly listed institutional crypto platform, has become the first participant in Mezo Prime. The firm has committed 250 BTC to the product, deploying a portion of its corporate treasury while keeping assets within its existing custody and compliance structure.
The launch reflects a broader shift in institutional crypto strategy, where firms are increasingly looking to optimize capital efficiency rather than hold digital assets passively.
By combining regulated custody, on-chain yield mechanisms, and strict asset segregation, Mezo Prime positions itself as infrastructure for institutional Bitcoin participation beyond simple storage.

Dan Burgin
U.Today Editorial Team